Vicriviroc (maleate)

Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570) .

Product Specifications

CAS Number

[599179-03-0]

Product Name Alternative

SCH-417690 (maleate) ; SCH-D (maleate)

UNSPSC

12352005

Hazard Statement

H302-H319-H373

Target

CCR; HIV

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Vicriviroc-maleate.html

Purity

99.91

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming)

Smiles

CC1(N2C[C@H](C)N([C@H](C3=CC=C(C(F)(F)F)C=C3)COC)CC2)CCN(C(C4=C(C)N=CN=C4C)=O)CC1.O=C(O)/C=C\C(O)=O

Molecular Formula

C32H42F3N5O6

Molecular Weight

649.70

Precautions

P260-P264-P270-P280-P305+P351+P338-P330-P501

References & Citations

[1]Tagat JR, et al. Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[ (4,6-dimethyl-5-pyrimidinyl) carbonyl]- 4-[4-[2-methoxy-1 (R) -4- (trifluoromethyl) phenyl]ethyl-3 (S) -methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist. J Med Chem. 2004 May 6;47 (10) :2405-8.|[2]Strizki JM, et al. Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2005 Dec;49 (12) :4911-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

CCR5; HIV-1

Available Sizes

Curated Selection

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