TPM1 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Tropomyosin 4

Gene Aliases

CMH3, TMSA, CMD1Y, LVNC9, C15orf13, HEL-S-265, HTM-alpha

Gene ID

7168

Swiss Prot

P09493

Accession Number

XP_006720731

Reactivity

Human, Mouse, Rat, Cow, Horse, Pig, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Human TPM1

Target

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

Partner Proteins

GOLGA2; CAGE1; C1orf216; SYCE1; KXD1; TFPT; MAD1L1; TPM4; TP53; TNNT1; UBC; MDM2; ETFA; FOXK1; KIAA1598; PPP6R3; APPL2; CDC37; MGEA5; STUB1; ABI2; DNAJC7; HSP90B1; PARK2; LRCH3; PAN2; TGFBR1; SPTBN1; ATF2; MDC1; BRCA1; PPP4R2; SRXN1; NUDCD2; RBM15; THOC2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

DAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKV

Applications

Purification

Affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol