SHANK2 antibody - C-terminal region (ARP64052_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

SH3 and multiple ankyrin repeat domains 2

Gene Aliases

SHANK, AUTS17, CORTBP1, CTTNBP1, ProSAP1, SPANK-3

Gene ID

22941

Swiss Prot

Q9UPX8-4

Accession Number

NP_036441

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

Target

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD) . Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain.

Partner Proteins

SHARPIN; NLK; LPHN1; DLGAP1; LPHN2; ARHGEF7; BAIAP2; DLG4; BAI2; DNM2; SSTR2; SLC9A3; CTTN; DLGAP3; DLGAP4; DLGAP2; DYNLL2; DYNLL1; MYO5A

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

PQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVD

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 85%; Guinea Pig: 77%; Horse: 100%; Human: 100%; Mouse: 85%; Rat: 85%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

135kDa

Protein Length

1254

NCBI Gene Symbol

SHANK2

Host or Source

Rabbit

Protein Name

SH3 and multiple ankyrin repeat domains protein 2

Gene Name URL

SHANK2

Nucleotide Accession Number

NM_012309

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