WASF1 Antibody

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Product Specifications

CAS Number

9007-83-4

Gene Name

WAS protein family, member 1

Gene Aliases

WAVE, SCAR1, WAVE1, NEDALVS

Gene ID

8936

Swiss Prot

Q92558

Accession Number

NP_003922

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the following sequence TPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKQKNLDRP

Target

The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP) -family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Partner Proteins

IFT20; TRIP10; PRKAR2A; PRKACA; ABL1; ZC3H15; TXNDC9; SORBS2; PTPN12; UBC; RYK; BRK1; SRGAP3; DNMBP; CYFIP2; PSTPIP1; NCKAP1; ACTR2; BAD; ABI1; RAC1; NCK1; NCF1; PFN1; CRK; IL12A; CXCL8; GNAI1; FYN; CDK5; CDC42; GRB2; ACTB; ACTG1; ARPC3; BAIAP2; ARHGEF2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

TPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKQKNLDRP

Applications

IHC

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 83%; Zebrafish: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

62 kDa

Protein Length

559

NCBI Gene Symbol

WASF1

Host or Source

Rabbit

Protein Name

Wiskott-Aldrich syndrome protein family member 1

Gene Name URL

WASF1

Nucleotide Accession Number

NM_001024934

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