PLAU antibody - C-terminal region (ARP63734_P050)
Product Specifications
CAS Number
9007-83-4
Gene Name
Plasminogen activator, urokinase
Gene Aliases
ATF, QPD, UPA, URK, u-PA, BDPLT5
Gene ID
5328
Swiss Prot
P00749
Accession Number
NP_002649
Reactivity
Human, Horse, Rabbit, Yeast
Target
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA) . HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
Partner Proteins
TEX101; UBC; PLAUR; SUMO1; NEDD8; CEBPG; ELAVL1; MYC; BTK; ALAS1; SCAMP5; PDGFC; ST14; SERPINA5; LRP2; SERPINF2; F2; SERPINB2; PLAT; SERPINE1; PLG; SERPINB6; IGF2R; HGF; NID1; CTSL; CTSB; MAP2K1; HRAS; SERPINE2
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
CSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Horse: 86%; Human: 100%; Rabbit: 86%; Yeast: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
28kDa
Protein Length
431
NCBI Gene Symbol
PLAU
Host or Source
Rabbit
Protein Name
Urokinase-type plasminogen activator
Gene Name URL
PLAU
Nucleotide Accession Number
NM_002658
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