TFRC Antibody - N-terminal region

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Product Specifications

CAS Number

9007-83-4

Gene Name

Transferrin receptor (p90, CD71)

Gene Aliases

T9, TR, TFR, p90, CD71, TFR1, TRFR, IMD46

Gene ID

7037

Swiss Prot

P02786

Accession Number

NP_003225

Reactivity

Human, Rabbit

Target

TFRC is a cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Partner Proteins

HUWE1; UBC; SGTA; CAV1; TP53; RAB8A; RANBP9; LGR4; MDM2; RPA3; RPA2; RPA1; ASB4; RNF2; OPTN; ADRB2; CLN3; MARCH8; env; MARCH1; MYO1G; VCAM1; ITGA4; FN1; ATF2; B4GALT1; ESR1; ATP6V1B1; FBXO6; KCNA5; KCNA3; vpu; SH3BP4; PARK2; LAPTM4B; LAPTM4A; HGS; SUMO2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

PVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPRE

Applications

WB, IHC

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol