TFRC Antibody - N-terminal region
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Product Specifications
CAS Number
9007-83-4
Gene Name
Transferrin receptor (p90, CD71)
Gene Aliases
T9, TR, TFR, p90, CD71, TFR1, TRFR, IMD46
Gene ID
7037
Swiss Prot
P02786
Accession Number
NP_003225
Reactivity
Human
Target
TFRC is a cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Partner Proteins
HUWE1; UBC; SGTA; CAV1; TP53; RAB8A; RANBP9; LGR4; MDM2; RPA3; RPA2; RPA1; ASB4; RNF2; OPTN; ADRB2; CLN3; MARCH8; env; MARCH1; MYO1G; VCAM1; ITGA4; FN1; ATF2; B4GALT1; ESR1; ATP6V1B1; FBXO6; KCNA5; KCNA3; vpu; SH3BP4; PARK2; LAPTM4B; LAPTM4A; HGS; SUMO2
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
GYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKLSE
Applications
IHC, WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
84kDa
Protein Length
760
NCBI Gene Symbol
TFRC
Host or Source
Rabbit
Protein Name
Transferrin receptor protein 1
Gene Name URL
TFRC
Nucleotide Accession Number
NM_003234
Curated Selection
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