MCAM Antibody - middle region
Product Specifications
CAS Number
9007-83-4
Gene Name
Melanoma cell adhesion molecule
Gene Aliases
CD146, MUC18, HEMCAM, METCAM, MelCAM
Gene ID
4162
Swiss Prot
P43121
Accession Number
NP_006491
Reactivity
Human, Cow, Horse, Pig, Rabbit
Target
MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. MCAM could be an adhesion molecule active in neural crest cells during embryonic development. MCAM acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Partner Proteins
ADRB2; UBC; HSP90AA5P; HSPA1L; ATF7IP; PTK2B; FYN
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
PSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQEL
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Cow: 86%; Horse: 86%; Human: 100%; Pig: 86%; Rabbit: 79%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
71kDa
Protein Length
646
NCBI Gene Symbol
MCAM
Host or Source
Rabbit
Protein Name
Cell surface glycoprotein MUC18
Gene Name URL
MCAM
Nucleotide Accession Number
NM_006500
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