ABI1 antibody - N-terminal region (ARP63431_P050)
Product Specifications
CAS Number
9007-83-4
Gene Name
Abl-interactor 1
Gene Aliases
E3B1, ABI-1, ABLBP4, NAP1BP, SSH3BP, SSH3BP1
Gene ID
10006
Swiss Prot
Q8IZP0
Accession Number
NP_005461
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Target
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t (10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
Partner Proteins
ABL1; UBC; PRPF40A; TCERG1; GAS7; APBB1; SRRM1; PRKAA1; PIK3R1; CDC123; CTTN; NCK2; NCK1; CBL; CACNA1A; RYK; EPS8L1; ENAH; MINK1; EVL; NIN; CYFIP2; HSPA8; WASF2; WASF1; PAK2; NCKAP1; ABI1; VASP; SOS2; EPS8; NCF1; SPTA1; SPTAN1; SOS1; NEB; EPS8L3; EPS8L2
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
HKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTL
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
56kDa
Protein Length
508
NCBI Gene Symbol
ABI1
Host or Source
Rabbit
Protein Name
Abl interactor 1
Gene Name URL
ABI1
Nucleotide Accession Number
NM_005470
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