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IL6ST Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

Interleukin 6 signal transducer (gp130, oncostatin M receptor)

Gene Aliases

CD130, GP130, HIES4, CDW130, IL-6RB, sGP130

Gene ID

3572

Swiss Prot

P40189-2

Accession Number

NP_786943

Reactivity

Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Target

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM) . This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis.

Partner Proteins

SGTB; KCNIP3; UBQLN1; UBC; MAGEA11; SOCS3; PTPN11; IL31RA; CDK9; LIF; OSMR; PIK3CG; IL6ST; CTF1; TLE1; AR; ERBB3; PRKCD; TYK2; PTPN6; PLAUR; OSM; VAV1; ERBB2; LIFR; IL6R; JAK1; IL6; HCK; CNTFR; CNTF; STAT3; SHC1; PIK3R1; JAK2; GRB2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

FTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKV

Applications

WB, IHC

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Rabbit: 77%; Rat: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

35kDa

Protein Length

329

NCBI Gene Symbol

IL6ST

Host or Source

Rabbit

Protein Name

Interleukin-6 receptor subunit beta

Gene Name URL

IL6ST

Nucleotide Accession Number

NM_175767

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