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NF2 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Neurofibromin 2 (merlin)

Gene Aliases

ACN, SCH, BANF, merlin-1

Gene ID

4771

Swiss Prot

P35240-4

Accession Number

NP_861968

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Target

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

Partner Proteins

VPRBP; CD44; UBC; KDM1A; AMOTL2; YAP1; PPP1R8; UBD; CCNB1IP1; HGS; CUL4A; DDB1; GPS1; WWC1; PYGO2; AMOT; SCHIP1; SGSM3; NF2; TSC1; TARBP2; SLC9A3R1; PAK1; XPO1; PXN; SDCBP; RALGDS; SPTBN1; ERBB2; ITGB1; EZR; CTNNB1; AGAP2; AKT1; RIT1; ARHGAP32; SOS1; MED2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

MAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPA

Applications

WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

56kDa

Protein Length

507

NCBI Gene Symbol

NF2

Host or Source

Rabbit

Protein Name

Merlin

Gene Name URL

NF2

Nucleotide Accession Number

NM_181830

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