Prnp Antibody - middle region
Product Specifications
CAS Number
9007-83-4
Gene Name
Prion protein
Gene Aliases
, AA960666, AI325101, prP27-30, prP33-35C
Gene ID
19122
Swiss Prot
P04925
Accession Number
NP_035300
Reactivity
Human, Rat, Cow, Dog, Goat, Sheep
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Mouse Prnp
Target
Prnp may play a role in neuronal development and synaptic plasticity, may be required for neuronal myelin sheath maintenance and may play a role in iron uptake and iron homeostasis. Prnp is a soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) . Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. It also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.
Partner Proteins
Dpp6; Eri3; Syn1; Grb2; Opcml; Lsamp; Ntm; Atp1a3; Igsf8; Cadm3; Clstn1; Pde10a; Adam23; Ywhaz; Ywhae; Stxbp1; Plp1; P4hb; Ncam2; Ncam1; Mog; Mbp; Mag; L1cam; Hspa5; Gnb1; Sparcl1; Dnm1; Dpysl2; Cntn1; Clu; Atp2b2; Atp1b1; Atp1a1; App; Apoe; Aplp2; Apbb1
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
GGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHF
Applications
WB, IHC
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Goat: 100%; Human: 100%; Rat: 100%; Sheep: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
28kDa
Protein Length
254
NCBI Gene Symbol
PRNP
Host or Source
Rabbit
Protein Name
Major prion protein
Gene Name URL
Prnp
Nucleotide Accession Number
NM_011170
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