BRCC3 Antibody - C-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Name
BRCA1/BRCA2-containing complex, subunit 3
Gene Aliases
C6.1A, BRCC36, CXorf53
Gene ID
79184
Swiss Prot
P46736
Accession Number
NP_077308
Reactivity
Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig, Rabbit
Target
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy.
Partner Proteins
FAM175B; UBC; FANCG; UIMC1; SUMO1; RABEP2; SMEK1; LARP7; CD2AP; WDHD1; SF3A1; GPHN; HNRNPR; TRIM28; HUWE1; MTA2; SPAG9; CCDC6; HDAC1; NR3C1; FAM175A; SUMO2; PAXIP1; MDC1; BRCA1; GRB2; BABAM1; BRE; BRCC3; COPS5; BACH1; BRCA2; BARD1; USP7; SHMT2; NDUFA10; M
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
HNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQELQQEKEELMQEL
Applications
IF, WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Cow: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 86%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
35kDa
Protein Length
316
NCBI Gene Symbol
BRCC3
Host or Source
Rabbit
Protein Name
Lys-63-specific deubiquitinase BRCC36
Gene Name URL
BRCC3
Nucleotide Accession Number
NM_024332
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