BAG4 Antibody - C-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Name
BCL2-associated athanogene 4
Gene Aliases
SODD, BAG-4
Gene ID
9530
Swiss Prot
B4E217
Accession Number
NP_001191807
Reactivity
Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Target
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Partner Proteins
EDC3; DCP1A; DNAJB12; DNAJC9; CD93; STUB1; DNAJB6; MLF2; DNAJC7; DNAJB1; HSPA8; HSPA2; HSPA1L; HSPA1B; DDX6; DCP1B; MCL1; CAND1; DCUN1D1; COPS5; CUL1; CUL2; CUL3; CUL4A; CUL5; NEDD8; ELAVL1; UBC; TNFRSF25; APOBEC1; TNFRSF1A; BCL2; HSPA1A; HSP90AA1; HSPA4
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
PSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNR
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Cow: 91%; Dog: 100%; Guinea Pig: 77%; Horse: 92%; Human: 100%; Pig: 100%; Rabbit: 92%; Rat: 92%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
46kDa
Protein Length
421
NCBI Gene Symbol
BAG4
Host or Source
Rabbit
Protein Name
BAG family molecular chaperone regulator 4
Gene Name URL
BAG4
Nucleotide Accession Number
NM_001204878
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