GIT2 Antibody - C-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Name
G protein-coupled receptor kinase interacting ArfGAP 2
Gene Aliases
PKL, CAT2, CAT-2
Gene ID
9815
Swiss Prot
Q14161
Accession Number
NP_476510
Reactivity
Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Target
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined.
Partner Proteins
UBC; QPRT; ATF5; CORO1A; HNRNPUL1; TNIP1; CALCOCO2; MVP; RUSC2; SAFB2; IKBKG; SPOP; TSN; TRAF1; TNFAIP3; RCVRN; PROX1; NME2; NFKBIB; SMAD3; LMNB1; KRT18; HGD; GUSB; GCH1; E2F2; C4BPA; ACTN1; ACTG1; Dlg4; POLR1B; USHBP1; RUFY1; SH3GLB2; KCTD5; UBQLN1; EDC4
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
VQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPE
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Pig: 100%; Rabbit: 93%; Rat: 79%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
83kDa
Protein Length
759
NCBI Gene Symbol
GIT2
Host or Source
Rabbit
Protein Name
ARF GTPase-activating protein GIT2
Gene Name URL
GIT2
Nucleotide Accession Number
NM_057169
Curated Selection
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