PRKAR2A Antibody-C-terminal region

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Product Specifications

CAS Number

9007-83-4

Gene Name

Protein kinase cAMP-dependent type II regulatory subunit alpha

Gene Aliases

PKR2, PRKAR2

Gene ID

5576

Swiss Prot

P13861

Accession Number

NP_004148

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PRKAR2A

Target

CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER) .

Partner Proteins

UBC; SUZ12; IMPDH2; GPS1; CSRP1; KPNA6; PRKACB; PRKACA; GCH1; WASF1; VCP; CIRBP; ELAVL1; PJA2; Dynll1; AKAP7; PPP1CB; MYCBPAP; ARFGEF2; AKAP2; RAB32; NBEA; AKAP12; AKAP11; AKAP10; AKAP8; AKAP6; AKAP3; AKAP5; AKAP13; AKAP9; CBFA2T3; SMAD3; AKAP1; CFTR; SMA

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

IESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAAS

Applications

Purification

Affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Dog: 86%; Horse: 85%; Human: 100%; Mouse: 86%; Pig: 85%; Rabbit: 92%; Rat: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

44 kDa

Protein Length

404

NCBI Gene Symbol

PRKAR2A

Host or Source

Rabbit

Protein Name

PKR2, PRKAR2

Gene Name URL

PRKAR2A

Nucleotide Accession Number

NM_004157.2

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