PPP1R12A Antibody - C-terminal region

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Product Specifications

CAS Number

9007-83-4

Gene Name

Protein phosphatase 1, regulatory subunit 12A

Gene Aliases

MBS, GUBS, M130, MYPT1

Gene ID

4659

Swiss Prot

O14974

Accession Number

NP_002471

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PPP1R12A

Target

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP) -bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase.

Partner Proteins

TP53; UBC; NUAK1; RPA3; RPA2; RPA1; TRIM47; AARSD1; PUS1; P3H1; RPRD1B; XPO5; OSGEP; NSUN2; NUSAP1; TTLL12; NUDT5; ARPC2; ACTR3; CUL1; TPP2; PFDN5; PFDN1; NRD1; PAN2; LATS1; gag; FMNL1; PAXIP1; IDH3G; CDV3; RHOA; LRRK2; ATXN10; SIAH2; FBXO25; ARRB2; ELAVL

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

QDSDENEQEQQSDTEEGSNKKETQTDSISRYETSSTSAGDRYDSLLGRSG

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol