TPR Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Translocated promoter region, nuclear basket protein

Gene ID

7175

Swiss Prot

P12270

Accession Number

NP_003283

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human TPR

Target

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs) . The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias.

Partner Proteins

STAU1; UBC; LGR4; MDM2; MAD1L1; EED; NPM1; LMNA; HDAC9; ITGA4; FN1; CBX7; BUD31; TAF15; TOP1; SNRPD1; SNRPA1; SRSF5; SFPQ; S100A9; RPL37A; RPL18A; RPL6; RBM4; RAN; PRKDC; NHP2L1; SEPT2; IK; HRAS; HNRNPU; HNRNPA2B1; EEF1D; EEF1B2; DDX3X; DDX1; DDB1; CIRBP

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

SQNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPP

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

267kDa

Protein Length

2363

NCBI Gene Symbol

TPR

Host or Source

Rabbit

Protein Name

Nucleoprotein TPR

Gene Name URL

TPR

Nucleotide Accession Number

NM_003292

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