TCHP Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Trichoplein, keratin filament binding

Gene Aliases

TpMs

Gene ID

84260

Swiss Prot

Q9BT92

Accession Number

NP_115676

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human TCHP

Target

TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.

Partner Proteins

CCDC172; MIPOL1; DYDC1; KRT40; LZTS2; NME7; NDOR1; MKRN3; TRIM27; NAB2; KRT15; CDR2; UBC; LATS2; CUL4A; CCDC85B; TEX11; VIM; KRT18; KRT16; KRT14; KRT8; KRT6A; KRT5

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

IQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol