TCHP Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Trichoplein, keratin filament binding

Gene Aliases

TpMs

Gene ID

84260

Swiss Prot

Q9BT92

Accession Number

NP_115676

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human TCHP

Target

TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.

Partner Proteins

CCDC172; MIPOL1; DYDC1; KRT40; LZTS2; NME7; NDOR1; MKRN3; TRIM27; NAB2; KRT15; CDR2; UBC; LATS2; CUL4A; CCDC85B; TEX11; VIM; KRT18; KRT16; KRT14; KRT8; KRT6A; KRT5

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

IQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Yeast: 91%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

61kDa

Protein Length

498

NCBI Gene Symbol

TCHP

Host or Source

Rabbit

Protein Name

Trichoplein keratin filament-binding protein

Gene Name URL

TCHP

Nucleotide Accession Number

NM_032300

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