What is the catalog number for SH2D1A antibody - C-terminal region (ARP60359_P050)?

The catalog number for SH2D1A antibody - C-terminal region (ARP60359_P050) is ARP60359_P050.

What sizes are available for SH2D1A antibody - C-terminal region (ARP60359_P050)?

SH2D1A antibody - C-terminal region (ARP60359_P050) is available in the following size(s): 100 µL.

Is SH2D1A antibody - C-terminal region (ARP60359_P050) in stock?

SH2D1A antibody - C-terminal region (ARP60359_P050) is currently made to order / not held in immediate stock. Contact us for lead time.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

SH2D1A antibody - C-terminal region (ARP60359_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

SH2 domain containing 1A

Gene Aliases

LYP, SAP, XLP, DSHP, EBVS, IMD5, XLPD, MTCP1, XLPD1, SAP/SH2D1A

Gene ID

4068

Swiss Prot

O60880

Accession Number

NP_002342

Reactivity

Human, Rat, Cow, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human SH2D1A

Target

SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.

Partner Proteins

LHX4; TNK2; UBC; LYN; MAPK11; MAPK1; ERBB3; EGFR; MAPK14; CD244; ELAVL1; SLAMF7; SLAMF6; ARHGEF7; CD84; SLAMF1; DOK1; FYB; LY9; ARHGEF6; LCK; FYN; GRB2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

YFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCL

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 86%; Horse: 92%; Human: 100%; Pig: 100%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

14kDa

Protein Length

128

NCBI Gene Symbol

SH2D1A

Host or Source

Rabbit

Protein Name

SH2 domain-containing protein 1A

Gene Name URL