DAXX Antibody - N-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Aliases
DAP6, EAP1, BING2, SMIM40
Gene ID
1616
Swiss Prot
Q9UER7
Accession Number
NP_001341
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human DAXX
Target
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
Partner Proteins
FAM9B; SSX2IP; SUMO1; UBE2I; UBC; GOLGA2; CARD9; PBXIP1; CDCA7L; NECAB2; RASSF1; PML; MDM2; H3F3A; DNMT1; TP53; ATRX; CARM1; PRMT1; WHSC1L1; CUL3; SPOP; HIPK2; PDCD4; DNMT3A; USP7; UBB; RELB; DAXX; CREB1; CBS; ATM; HIST1H4F; HIST1H3C; TRAF3; HIST4H4; BTBD
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
KLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSRRQIQRL
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
81kDa
Protein Length
740
NCBI Gene Symbol
DAXX
Host or Source
Rabbit
Gene Name URL
DAXX
Frequently Asked Questions
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