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CD22 Antibody - C-terminal region

Product Specifications

Gene Name

CD22 molecule

Gene Aliases

SIGLEC2, SIGLEC-2

Gene ID

933

Swiss Prot

P20273

Accession Number

NP_001762

Reactivity

Human, Horse

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human CD22

Target

CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins; one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Partner Proteins

UBC; CD19; INPP5D; LCP2; AP2M1; SHC1; SYK; PTPN6; PLCG1; PIK3R1; LYN; PTPRC; IGHM; HP; ST6GAL1; ATP2B4; GRB2; AP2A1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

YSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVIL

Applications

WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Horse: 79%; Human: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

95kDa

Protein Length

847

NCBI Gene Symbol

CD22

Host or Source

Rabbit

Protein Name

B-cell receptor CD22

Gene Name URL

CD22

CAS Number

9007-83-4

Nucleotide Accession Number

NM_001771

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