BTBD12 Antibody - N-terminal region

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Product Specifications

CAS Number

9007-83-4

Gene Name

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

Gene Aliases

FANCP, BTBD12, MUS312

Gene ID

84464

Swiss Prot

Q8IY92

Accession Number

NP_115820

Reactivity

Human, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human BTBD12

Target

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4 (XPF) -ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2 (TRF2) -TERF2IP (RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.

Partner Proteins

MUS81; vpr; SLX1A; SLX1B; DCLRE1B; TERF2; ERCC4; UBC; ERCC1; APP; EME1; PCNA; MSH2; MSH6; DDB1; SLX4IP; SPRTN; TERF2IP; VCP; PLK1; SUMO2; PGAM5; DCAF10; LRRC1; GID8; TEX10; GLTSCR2; NUP188; NUP50; PNMA2; TSPYL1; PSMB4; MSH3; KPNA1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

TKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPD

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Human: 100%; Rabbit: 91%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

200kDa

Protein Length

1834

NCBI Gene Symbol

SLX4

Host or Source

Rabbit

Protein Name

Structure-specific endonuclease subunit SLX4

Gene Name URL

SLX4

Nucleotide Accession Number

NM_032444

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