RASSF1 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Ras association (RalGDS/AF-6) domain family member 1

Gene Aliases

123F2, RDA32, NORE2A, RASSF1A, REH3P21

Gene ID

11186

Swiss Prot

Q9NS23

Accession Number

NP_733831

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human RASSF1

Target

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Partner Proteins

FBXW11; MDM2; DAXX; SUV39H2; KDM1A; SUV39H1; STK4; STK3; CDC20; SAV1; MAST2; HUWE1; LATS1; BTRC; UBC; ID1; GSK3B; C7orf25; C8orf33; KCNE3; CUL4A; DDB1; Rassf1; SKP2; AURKB; AURKA; SKP1; CUL1; NUDT10; MOAP1; CNKSR1; MAP1S; EXOSC8; RASSF5; TNFRSF10A; E4F1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

LAGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQIL

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol