SPR Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)

Gene Aliases

SDR38C1

Gene ID

6697

Swiss Prot

P35270

Accession Number

NP_003115

Reactivity

Human, Mouse, Rat, Dog, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human SPR

Target

This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4) . Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.

Partner Proteins

UBC; YWHAQ; MRPL53; SRPRB; SUGP1; SBDS; AHCYL1; SCO2; RAD23B; PPM1G; NDUFA2; IDH3G; CRK; ASS1; CAMK2G

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

ETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYD

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Dog: 79%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 86%; Rat: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

28kDa

Protein Length

261

NCBI Gene Symbol

SPR

Host or Source

Rabbit

Protein Name

Sepiapterin reductase

Gene Name URL

SPR

Nucleotide Accession Number

NM_003124

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