USP20 antibody - middle region (ARP59314_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

Ubiquitin specific peptidase 20

Gene Aliases

VDU2, hVDU2, LSFR3A

Gene ID

10868

Swiss Prot

Q9Y2K6

Accession Number

NP_006667

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human USP20

Target

USP20 is a deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2) . USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. USP20 deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity.USP20 mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Partner Proteins

MDFI; MAGEA11; TRIM23; ALAS1; FATE1; BEND5; SPRY2; VAPB; CCDC36; BEND7; RAD17; NEURL4; USP33; USP20; CCP110; ADRB2; PJA1; USP28; USP21; USP15; PLA2G2A; UBC; VHL; HIF1A; VAPA; HERC2P2; PLEKHA7; SYTL4; GPT2; POLDIP3; RGPD5; ATAD3B; MAP7D1; LRRC59; ZNF770; S

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

PAEAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPP

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 92%; Dog: 92%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 85%; Rabbit: 100%; Rat: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

102kDa

Protein Length

913

NCBI Gene Symbol

USP20

Host or Source

Rabbit

Protein Name

Ubiquitin carboxyl-terminal hydrolase 20

Gene Name URL

USP20

Nucleotide Accession Number

NM_006676

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