IL7R Antibody - middle region
Product Specifications
CAS Number
9007-83-4
Gene Name
Interleukin 7 receptor
Gene Aliases
ILRA, CD127, IL7RA, CDW127, IL-7R-alpha
Gene ID
3575
Swiss Prot
P16871
Accession Number
NP_002176
Reactivity
Human, Dog, Horse
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human IL7R
Target
The protein encoded by this gene is a receptor for interleukine 7 (IL7) . The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V (D) J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID) .
Partner Proteins
KIT; JAK3; SNRPG; SNRPD3; SNRPD2; SNRPD1; SNRPB; SNRPA; SNRNP70; SRSF3; SAFB; RPS20; RPS3; RPL31; RPL29; RPL30; RPL22; RPL18; RPL15; RPL8; RPL7; RPL6; RBM3; PURB; PURA; PTMA; PTBP1; EIF2AK2; YBX1; NONO; NCL; MAP4; RPSA; ILF3; ILF2; HNRNPU; HNRNPL; HNRNPH3
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
ESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCP
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Dog: 92%; Horse: 83%; Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
49kDa
Protein Length
459
NCBI Gene Symbol
IL7R
Host or Source
Rabbit
Protein Name
Interleukin-7 receptor subunit alpha
Gene Name URL
IL7R
Nucleotide Accession Number
NM_002185
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