TLR4 antibody - middle region (ARP59041_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

Toll-like receptor 4

Gene Aliases

TOLL, CD284, TLR-4, ARMD10

Gene ID

7099

Swiss Prot

O00206

Accession Number

NP_612564

Reactivity

Human, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TLR4

Target

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.

Partner Proteins

TNFSF9; SRC; SYK; SMAD3; SERTAD1; BTK; TICAM1; HGS; UBC; HSPA4; TICAM2; STK11IP; TIRAP; TRAF3; TRIM69; IRAK4; TBK1; STUB1; TRAF6; PRKCZ; MYD88; IRAK1; HSPA8; RNF216; CNPY4; SIGIRR; MAPK8IP3; NOX4; TOLLIP; LY96; BCL10; RIPK2; IRAK2; TLR5; DEFB4A; TLR1; HSP

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

LGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTN

Applications

IHC, WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol