CASP10 antibody - middle region (ARP59000_P050)
Product Specifications
CAS Number
9007-83-4
Gene Name
Caspase 10, apoptosis-related cysteine peptidase
Gene Aliases
MCH4, ALPS2, FLICE2, FLICE-2
Gene ID
843
Swiss Prot
Q92851
Accession Number
NP_001221
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CASP10
Target
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Partner Proteins
FADD; PRDX6; XIAP; RB1; Dlg4; PHF20L1; OIP5; ECE2; RIOK3; NFKBIL1; CASP8; RNF34; BFAR; CASP8AP2; MSN2; PTC2; AIM9; GLN3; SLT2; GPA1; STE20; ATG13; RPL21B; VPS30; CUP9; TPK2; GAL4; FAR11; WHI3; ATG4; FAR3; FAR8; ITT1; MPH1; SSM4; ASG1; BFR1; ORT1; MBR1; CW
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
HNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIP
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
12kDa
Protein Length
479
NCBI Gene Symbol
CASP10
Host or Source
Rabbit
Protein Name
Caspase-10
Gene Name URL
CASP10
Nucleotide Accession Number
NM_001230
Curated Selection
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