CASP4 Antibody - middle region
Product Specifications
CAS Number
9007-83-4
Gene Name
Caspase 5, apoptosis-related cysteine peptidase
Gene Aliases
TX, Mih1, ICH-2, Mih1/TX, ICEREL-II, ICE (rel) II
Gene ID
837
Swiss Prot
P49662-2
Accession Number
NP_150649
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human CASP4
Target
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Partner Proteins
MYH9; ELF4; APP; TRAF6; PLA2G4A; NOD1; CASP14; CASP4; APAF1; SERPINB9; CASP10; IL18; CASP3; IL1B; DSP; PSEN1; IL37; CASP8; CASP1; XIAP; MYCBPAP; SLC25A22; SRPRB; CTNNBIP1; DNAAF5; MTHFD1L; UFL1; GCN1L1; SMC2; NUP93; SMC3; SMC1A; USP9X; VDAC3; PSMB1; MSH6
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGEL
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
35kDa
Protein Length
321
NCBI Gene Symbol
CASP4
Host or Source
Rabbit
Protein Name
Caspase-4
Gene Name URL
CASP4
Nucleotide Accession Number
NM_033306
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