PSEN1 Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

Presenilin 1

Gene Aliases

AD3, FAD, PS1, PS-1, S182, ACNINV3

Gene ID

5663

Swiss Prot

P49768

Accession Number

NP_000012

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PSEN1

Target

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Partner Proteins

UBC; TRAF6; TGFBR1; ERLIN2; PSMB1; PSMA5; ETFA; TDP2; PSEN2; PSEN1; APH1B; PSENEN; APH1A; NCSTN; ITSN2; PDCD4; KANK2; EPB41L3; CDC37; TUBA1B; AP1M2; UMPS; PRDX2; ST13; SCN1A; RHEB; RAD23A; RAB3A; OXCT1; NOS3; NDUFS8; HMGB1; GCDH; GAPDH; FGF13; ENSA; DTNA

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

EGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLG

Applications

IHC, IP, WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 85%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

52 kDa

Protein Length

467

NCBI Gene Symbol

PSEN1

Host or Source

Rabbit

Protein Name

Presenilin-1

Gene Name URL

PSEN1

Nucleotide Accession Number

NM_000021

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