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SHB Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Src homology 2 domain containing adaptor protein B

Gene Aliases

BA3J10.2

Gene ID

6461

Swiss Prot

Q15464

Accession Number

NP_003019

Reactivity

Human, Mouse, Rat, Cow, Dog, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SHB

Target

SHB is the adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. SHB may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. SHB may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. SHB may also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Partner Proteins

SLC39A1; GRAP2; LAT; LCP2; EPS8; JAK3; IL2RG; KDR; SRC; ZAP70; PDGFRA; PLCG1; PIK3R1; VAV1; CRK; JAK1; IL2RB; GRB2; FGFR1; PDGFRB

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

ERPSQPPQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSDLIRAY

Applications

WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

55kDa

Protein Length

509

NCBI Gene Symbol

SHB

Host or Source

Rabbit

Protein Name

SH2 domain-containing adapter protein B

Gene Name URL

SHB

Nucleotide Accession Number

NM_003028

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