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GARS Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

Glycyl-tRNA synthetase

Gene Aliases

GARS, HMN5, CMT2D, DSMAV, GlyRS, HMN5A, SMAD1, SMAJI

Gene ID

2617

Swiss Prot

P41250

Accession Number

NP_002038

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human GARS

Target

GARS catalyzes the attachment of glycine to tRNA (Gly) . Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha) 2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

UBC; STAU1; NEDD8; DCP2; TNRC6B; CAND1; GORASP2; CORO1C; BOP1; GANAB; XPO7; HSPA4L; VAT1; SEC23A; TOM1; KHSRP; HIRIP3; HIST1H4A; USP11; ZYX; UGDH; TTC1; TROVE2; SNX1; SHMT1; PPM1G; OSBP; NCBP1; ME1; GTF2A1; GFPT1; CTTN; CTNNA1; CARS; APEH; MAPK8; MAP3K10

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

IEPSFGLGRIMYTVFEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLSQN

Applications

WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

83kDa

Notes

Formerly GWB-MV376G

Protein Length

739

NCBI Gene Symbol

GARS

Host or Source

Rabbit

Protein Name

Glycine--tRNA ligase

Gene Name URL

GARS

Nucleotide Accession Number

NM_002047

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