TNKS1BP1 Antibody - middle region

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Product Specifications

CAS Number

9007-83-4

Gene Name

Tankyrase 1 binding protein 1, 182kDa

Gene Aliases

TAB182

Gene ID

85456

Swiss Prot

Q9C0C2

Accession Number

NP_203754

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TNKS1BP1

Target

TNKS-1 mRNA in urine sediment from patients with bladder TCC correlated with tumor stage, and higher preoperative levels were associated with increased risk of early recurrence. Tankyrase-1 is required in the assembly of bipolar spindles and the spindle-pole protein NuMA as a substrate for covalent modification by tankyrase-1. Data also show that tankyrase 1 inhibition in human cancer cells enhances telomere shortening by a telomerase inhibitor and hastens cell death.

Partner Proteins

UBC; RNF219; SPC25; RABGEF1; DCTN3; SPTBN1; NLK; CSNK2A1; CNOT6L; CNOT6; VCP; HNRNPK; DYNC1H1; CBX3; SIRT7; TSG101; Cnot3; Capza1; TNKS2; TNKS

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

DGEASQTEDVDGTWGSSAARWSDQGPAQTSRRPSQGPPARSPSQDFSFIE

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Human: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

190kDa

Protein Length

1729

NCBI Gene Symbol

TNKS1BP1

Host or Source

Rabbit

Protein Name

182 kDa tankyrase-1-binding protein

Gene Name URL

TNKS1BP1

Nucleotide Accession Number

NM_033396

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