POT1 antibody - middle region (ARP58317_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

Protection of telomeres 1 homolog (S. pombe)

Gene Aliases

GLM9, CMM10, HPOT1

Gene ID

25913

Swiss Prot

Q9NUX5

Accession Number

NP_056265

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human POT1

Target

This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.

Partner Proteins

TPP1; CFL2; ACD; CORO1A; KHDRBS1; LAMC3; BCAS2; MVP; ZNF32; ECI1; CSNK2B; COX6A2; ALDH1A1; ACTN4; SERTAD1; C2orf74; ZBTB49; ZBED2; CYP4F11; MYO5C; RIF1; NAP1L1; MDM2; KRT18; GRN; PACSIN1; SULT4A1; PGLS; AIPL1; SH3BP1; HAAO; NCDN; TWF2; ACOT7; DDX19B; PACS

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

MNSENQTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLTAN

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 93%; Rat: 93%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

70kDa

Protein Length

634

NCBI Gene Symbol

POT1

Host or Source

Rabbit

Protein Name

Protection of telomeres protein 1

Gene Name URL

POT1

Nucleotide Accession Number

NM_015450

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