RB1 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Retinoblastoma 1

Gene Aliases

RB, pRb, OSRC, pp110, p105-Rb, PPP1R130, p110-RB1

Gene ID

5925

Swiss Prot

P06400

Accession Number

NP_000312

Reactivity

Human, Mouse, Rat, Cow, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human RB1

Target

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Partner Proteins

RAF1; E2F1; ABL1; HDAC1; KDM2A; SMARCA4; USP7; UBC; DYRK1A; NEFM; DYRK1B; MAGEA11; ENC1; PPP1CA; CDKN1C; CDKN1A; CDK6; CDK4; CDK2; CCNE1; CCNA2; CCND1; HDAC11; PAX5; HIF1A; E2F4; CEBPE; CCNA1; SUMO1; UBE2I; TFAP2A; CDK3; CDK1; CCNC; CCNB1; MRPS18B; SUMO2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFE

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol