APEX1 Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

APEX nuclease (multifunctional DNA repair enzyme) 1

Gene Aliases

APE, APX, APE1, APEN, APEX, HAP1, REF1

Gene ID

328

Swiss Prot

P27695

Accession Number

NP_001632

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human APEX1

Target

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Partner Proteins

GADD45A; UBC; RPA3; RPA2; RPA1; rev; CCDC124; RIC8A; PABPC1; TWF2; XPOT; HNRNPUL1; ARIH2; PAPSS2; NAE1; PSMG1; TXNRD1; TXN; TCEB1; LGALS1; HNRNPK; CAPNS1; SRPK2; SRPK1; MUTYH; HMGA1; HMGA2; GZMK; GZMA; YBX1; EP300; ASCL2; STAT3; SNRPD1; SFPQ; APP; UBE2I

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

HEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAY

Applications

WB, IHC

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

36 kDa

Protein Length

318

NCBI Gene Symbol

APEX1

Host or Source

Rabbit

Protein Name

DNA- (apurinic or apyrimidinic site) lyase

Gene Name URL

APEX1

Nucleotide Accession Number

NM_001641

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