RIC8A antibody - N-terminal region (ARP57567_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)

Gene Aliases

RIC8

Gene ID

60626

Swiss Prot

Q9NPQ8-3

Accession Number

NP_068751

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human RIC8A

Target

RIC8A is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.RIC8A is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.RIC8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) -alpha protein, possibly leading to release G (i) -alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) -alpha-GDP complex. RIC8A also acts as an activator for G (q) -alpha (GNAQ) protein by enhancing the G (q) -coupled receptor-mediated ERK activation.

Partner Proteins

NECAB2; UBQLN1; RABAC1; UBC; EFEMP1; SDCBP; NUTM1; SARNP; WDR61; DPP7; PAPSS2; EZR; UBA1; RPL38; PYGB; PLCG1; MC1R; APEX1; GNAQ; XPO1; GNAI1; UBQLN4; ZNF585B; RIC8A; MAPK8IP3; GNA13; TERF1; GNAI3; GNAI2; GNAS; GNAO1; TUBB2A

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

KLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLL

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol