CALCOCO1 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Calcium binding and coiled-coil domain 1

Gene Aliases

Cocoa, PP13275, calphoglin

Gene ID

57658

Swiss Prot

Q9P1Z2

Accession Number

NP_065949

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human CALCOCO1

Target

CALCOCO1 functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR) .CALCOCO1 is recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation CALCOCO1 acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. CALCOCO1 is involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. CALCOCO1 functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions.

Partner Proteins

CWF19L2; CEP19; FAM161A; TBC1D15; DUSP13; ISOC1; GABARAPL2; NDC80; UBC; GRIK2; APP; APTX; EP300; CTNNB1; NEDD4; HIST1H4A; HIST1H3A; PCBD1; TBC1D17; CTNNBL1; CYTH3; SH3GL3; CRYBA2; CREBBP; MAPK1; KRT15; IPP; FOSL1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

ESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFRE

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol