LRDD antibody - N-terminal region (ARP57269_P050)

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Product Specifications

CAS Number

9007-83-4

Gene Name

P53-induced death domain protein 1

Gene Aliases

LRDD, PIDD

Gene ID

55367

Swiss Prot

Q9HB75-3

Accession Number

NP_060964

Reactivity

Human, Mouse, Rat

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human LRDD

Target

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6) -associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.

Partner Proteins

CRADD; CRYAB; MDFI; SOX8; KEAP1; TEAD3; MAFG; AFP; RPAP3; FANCI; SENP3; TRIM32; ANP32B; HAX1; TELO2; NUP93; AIFM1; RFC5; RFC4; PRKDC; PPP6C; POLR2B; POLD1; PCNA; PRDX1; MCM7; ERCC5; ERCC2; DDB1; CASP2; FADD; RIPK1; IKBKG; CCDC85B; EFEMP2; MADD

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

RLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLA

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol