2-Ketoglutaric acid-13C5

2-Ketoglutaric acid-13C5 (Alpha-Ketoglutaric acid-13C5) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) [1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) [2].

Product Specifications

CAS Number

[161096-83-9]

Product Name Alternative

Alpha-Ketoglutaric acid-13C5

UNSPSC

12352211

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Tyrosinase

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-ketoglutaric-acid-13c5.html

Purity

99.1

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[13C]([13CH2][13CH2][13C]([13C](O)=O)=O)=O

Molecular Formula

13C5H6O5

Molecular Weight

151.06

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79 (4) :419-35.|[3]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec105 (Pt 3) :1654-1662.