PMS2 Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

PMS2 postmeiotic segregation increased 2 (S. cerevisiae)

Gene Aliases

MLH4, PMSL2, HNPCC4, MMRCS4, PMS2CL

Gene ID

5395

Swiss Prot

P54278

Accession Number

NP_000526

Reactivity

Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PMS2

Target

PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Partner Proteins

UBC; MLH1; PCNA; PMS2P1; NSF; MSH2; LMNA; MSH6; SPRTN; BRIP1; FAN1; CLSPN; TOPBP1; PSD2; MMS19; ATAD3A; NSUN2; UBR5; COPG2; PSD3; COPG1; RUVBL2; EXO1; AIFM1; RUVBL1; XPO1; SMARCA4; RFC2; PSMD5; PSMC6; PSMC3; PSMC2; PSMC1; PRKDC; PPP2CA; PIK3C2A; MSH3; MCM

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

INKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 85%; Dog: 92%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Rabbit: 92%; Rat: 92%; Yeast: 91%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

96kDa

Protein Length

862

NCBI Gene Symbol

PMS2

Host or Source

Rabbit

Protein Name

Mismatch repair endonuclease PMS2

Gene Name URL

PMS2

Nucleotide Accession Number

NM_000535

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

RG222854 10 µg

CaV1.3 (CACNA1D) (NM_000720) Human Tagged ORF Clone

Ask

View Details

MBS2065248-01 0.1 mL

APC/CY7-Linked Polyclonal Antibody to Calcium And Integrin Binding Protein 1 (CIB1)

Ask

View Details

MBS2065248-02 0.2 mL

APC/CY7-Linked Polyclonal Antibody to Calcium And Integrin Binding Protein 1 (CIB1)

Ask

View Details

MBS2065248-03 0.5 mL

APC/CY7-Linked Polyclonal Antibody to Calcium And Integrin Binding Protein 1 (CIB1)

Ask

View Details

MBS2065248-04 1 mL

APC/CY7-Linked Polyclonal Antibody to Calcium And Integrin Binding Protein 1 (CIB1)

Ask

View Details

MBS2065248-05 5 mL

APC/CY7-Linked Polyclonal Antibody to Calcium And Integrin Binding Protein 1 (CIB1)

Ask

View Details