IARS Antibody - middle region

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Product Specifications

CAS Number

9007-83-4

Gene Name

Isoleucyl-tRNA synthetase

Gene Aliases

IRS, IARS, ILRS, ILERS, GRIDHH, PRO0785

Gene ID

3376

Swiss Prot

P41252

Accession Number

NP_038203

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human IARS

Target

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs.

Partner Proteins

UBC; MDM2; SART3; AURKA; SUMO2; SUMO3; STAU1; LGR4; AIMP2; RPLP0; RPL38; RPL24; RPL23A; RPL18; RPL15; QARS; NMT1; MARS; MAP4; HNRNPA2B1; EPRS; DARS; AIMP1; HNRNPUL2; LARS; RPS27L; IGF2BP3; SYNCRIP; EEF1E1; FBXO6; EGFR; UBD; ITGA4; FN1; METTL18; gag; VCAM1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

YEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVLPTTAD

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 85%; Dog: 85%; Guinea Pig: 93%; Horse: 85%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

144kDa

Protein Length

1262

NCBI Gene Symbol

IARS

Host or Source

Rabbit

Protein Name

Isoleucine--tRNA ligase, cytoplasmic

Gene Name URL

IARS

Nucleotide Accession Number

NM_013417

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