LYN Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Gene Aliases

JTK8, p53Lyn, p56Lyn

Gene ID

4067

Swiss Prot

P07948

Accession Number

NP_002341

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human LYN

Target

LYN down regulates expression of stem cell growth factor receptor (KIT) .LYN acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation.LYN acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents.LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.

Partner Proteins

UBC; IKBKG; TRIM28; EGFR; RGS16; TNF; IL1B; ANGPT2; DKFZP434K028; CNOT10; TGDS; CBX6; FBXO28; ZNF423; RASSF8; FRS2; HBS1L; TUBB4A; SH2D3C; RIMS2; DDX21; KYNU; TNFSF12; PIK3R3; YEATS4; ZNF189; UGP2; HSP90B1; TADA2A; SLC12A4; RDX; PRKCB; SCIMP; LNP1; RNF180

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

DPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSF

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%; Sheep: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

58kDa

Protein Length

512

NCBI Gene Symbol

LYN

Host or Source

Rabbit

Protein Name

Tyrosine-protein kinase Lyn

Gene Name URL

LYN

Nucleotide Accession Number

NM_002350

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

KC-43338-01 50 μL

CDHR4 Antibody

Ask

View Details

KC-43338-02 100 µL

CDHR4 Antibody

Ask

View Details

KC-43338-03 1 mL

CDHR4 Antibody

Ask

View Details

38561066 1.0 µg DNA

RASSF9 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

Ask

View Details

PM202 100 µg

Cynomolgus ACVR2B Protein, Fc Tag

Ask

View Details

bsm-61438R-BF555-01 20 µL

GH1 Recombinant Antibody, AbBy Fluor™ 555 Conjugated

Ask

View Details