GRN Antibody - middle region
Product Specifications
CAS Number
9007-83-4
Gene Name
Granulin
Gene Aliases
GEP, GP88, PEPI, PGRN, CLN11, PCDGF
Gene ID
2896
Swiss Prot
P28799-2
Accession Number
NP_002078
Reactivity
Human, Cow, Dog, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human GRN
Target
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Partner Proteins
OTX1; HOXA1; DLX2; SGTA; KRTAP26-1; KRTAP10-7; CCDC33; ARFGAP1; FANCL; NLK; GLRX3; EED; HECW2; Hk3; RPS6KA1; NPM1; POT1; FRAT1; YY1; TGM2; RAC1; PRKAB2; PIK3R2; SMAD9; KRT18; CRY1; CFTR; CCNG1; FBXO6; GFI1B; ATN1; CDK2; CRKL; VHL; SIRT3; ATXN7; CACNA1A; C
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
CPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGD
Applications
WB, IHC
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Cow: 92%; Dog: 92%; Horse: 92%; Human: 100%; Rabbit: 85%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
47 kDa
Protein Length
438
NCBI Gene Symbol
GRN
Host or Source
Rabbit
Protein Name
Granulins
Gene Name URL
GRN
Nucleotide Accession Number
NM_002087
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