UBE4B Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Ubiquitination factor E4B

Gene Aliases

E4, UFD2, HDNB1, UBOX3, UFD2A

Gene ID

10277

Swiss Prot

O95155

Accession Number

NP_001099032

Reactivity

Human, Dog, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human UBE4B

Target

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B is an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. The gene that encodes the protein is also the strongest candidate in the neuroblastoma tumor suppressor genes. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Partner Proteins

TRIP12; UBC; FBXW11; HGS; STAM; TP53; MDM2; NUSAP1; NUDCD3; RBM12; PDE3A; CDKN2A; UBL7; UBE2D3; CDC27; TTK; IGBP1; HDLBP; TTC9C; MRPL53; ZFYVE19; SARNP; SRPRB; VPS35; UBA6; VPS29; UFM1; SBDS; VPS36; UBQLN1; UBXN7; UBE2C; AHCYL1; SSSCA1; SF3B4; PPIF; SCO2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

SPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAASQL

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol