Usp21 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Ubiquitin specific peptidase 21

Gene Aliases

Usp, ESTM2, Usp16, Usp23, ESTM28, W53272

Gene ID

30941

Swiss Prot

Q9QZL6

Accession Number

NP_038947

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Usp21

Target

Usp21 deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Usp21 regulates gene expression via histone H2A deubiquitination. It is also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.

Partner Proteins

Eed; TGFBR1; ACVR1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

PLPPRPGPPDERLKKLELGRGRTSGSRPRGPLRADHGVPLPGSPPPAVAL

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

63 kDa

Protein Length

566

NCBI Gene Symbol

USP21

Host or Source

Rabbit

Protein Name

Ubiquitin carboxyl-terminal hydrolase 21

Gene Name URL

Usp21

Nucleotide Accession Number

NM_013919

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