PIAS2 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Protein inhibitor of activated STAT, 2

Gene Aliases

DIP, MIZ1, SIZ2, ARIP3, PIASX, ZMIZ4

Gene ID

9063

Swiss Prot

O75928-2

Accession Number

NP_775298

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human PIAS2

Target

Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described.

Partner Proteins

HIC1; GOLGA2; GFAP; PHC1; TRIM23; ZBTB8A; SUMO1P1; ACY3; TSR2; NAV2; CCHCR1; CCNDBP1; MAPKAPK2; ZBED1; PIAS2; SUMO1; UBE2I; TP53; PRKAB2; MX2; TRIM63; TRIM55; CTBP1; GTF2I; SUMO2; SUMO3; MYC; DNMT3A; TICAM2; RUFY1; PIAS4; C1QA; ADA; PAXIP1; UBC; PLAGL1; P

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

RELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSSPVEPDLAVAGIHSLPST

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 92%; Guinea Pig: 92%; Horse: 92%; Human: 100%; Mouse: 92%; Pig: 93%; Rabbit: 92%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

63kDa

Protein Length

572

NCBI Gene Symbol

PIAS2

Host or Source

Rabbit

Protein Name

E3 SUMO-protein ligase PIAS2

Gene Name URL

PIAS2

Nucleotide Accession Number

NM_173206

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