Z-Ile-Leu-aldehyde
Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2].
Product Specifications
CAS Number
161710-10-7
Product Name Alternative
Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII
UNSPSC
12352005
Target
Apoptosis; Notch; γ-secretase
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Z-Ile-Leu-aldehyde.html
Purity
98.0
Solubility
DMSO : ≥ 41 mg/mL
Smiles
O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C=O)CC(C)C)=O)[C@@H](C)CC
Molecular Formula
C20H30N2O4
Molecular Weight
362.46
References & Citations
[1]Reem Suleiman, et al. The Role Of Notch In Th17 Differentiation. University of Massachusetts Amherst. 9-2013.|[2]Schwarzer R, et al. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J. 2014 Jun 13;4:e217.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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